Blood pressure thresholds for the diagnosis of hypertensive disorders of pregnancy in sickle cell disease.
Publication/Presentation Date
3-1-2024
Abstract
In this retrospective cohort study of singleton pregnancies in people with sickle cell disease (SCD) delivered at two academic centres between 1990 and 2021, we collected demographic and SCD-related data, pregnancy outcomes, and the highest systolic and diastolic blood pressure (SBP and DBP) at seven time periods. We compared the characteristics of subjects with new or worsening proteinuria (NWP) during pregnancy to those without. We then constructed receiver operating characteristic (ROC) curves to determine the blood pressure (BP) that best identifies those with NWP. The SBP or DBP thresholds which maximized sensitivity and specificity were 120 mmHg SBP (sensitivity: 55.2%, specificity: 73.5%) and 70 mmHg DBP (sensitivity: 27.6%, specificity: 67.7%). The existing BP threshold of 140/90 mmHg lacked sensitivity in both genotype groups (HbSS/HbSβ
Volume
204
Issue
3
First Page
1039
Last Page
1046
ISSN
1365-2141
Published In/Presented At
Early, M. L., Raja, M., Luo, A., Solow, M., Matusiak, K., Eke, A. C., Shehata, N., Kuo, K. H. M., Lanzkron, S., Malinowski, A. K., & Pecker, L. H. (2024). Blood pressure thresholds for the diagnosis of hypertensive disorders of pregnancy in sickle cell disease. British journal of haematology, 204(3), 1039–1046. https://doi.org/10.1111/bjh.19248
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
38093478
Department(s)
Administration and Leadership
Document Type
Article