Natural history of blood pressure in sickle cell disease pregnancy.

Authors

• Macy L Early
• Amy Luo
• Marissa Solow
• Kristine Matusiak
• Ahizechukwu C Eke
• Nadine Shehata
• Phyllis August
• Kevin H M Kuo
• Sophie Lanzkron
• Ann Kinga Malinowski
• Lydia H Pecker

Publication/Presentation Date

2-1-2024

Abstract

In this retrospective cohort study of singleton pregnancies in people with sickle cell disease (SCD) delivered at two academic centres between 1990 and 2021, we collected demographic and SCD-related data, pregnancy outcomes, and the highest systolic and diastolic blood pressure (SBP and DBP) at seven time periods. We compared blood pressure values and trajectories in the composite cohort and in each genotype group to control values in a non-SCD pregnancy dataset. There were 290 pregnancies among 197 patients with SCD. Sixteen per cent (n = 47) of pregnancies had a hypertensive disorder of pregnancy (HDP); the rates did not differ by genotype. The mean SBP and DBP were lower in the HbSS/HbSβ

Volume

204

Issue

2

First Page

658

Last Page

667

ISSN

1365-2141

Published In/Presented At

Early, M. L., Luo, A., Solow, M., Matusiak, K., Eke, A. C., Shehata, N., August, P., Kuo, K. H. M., Lanzkron, S., Malinowski, A. K., & Pecker, L. H. (2024). Natural history of blood pressure in sickle cell disease pregnancy. British journal of haematology, 204(2), 658–667. https://doi.org/10.1111/bjh.19133

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

37803527

Department(s)

Administration and Leadership

Document Type

Article