Analysis of the olfactory mucosa in chronic rhinosinusitis.
Publication/Presentation Date
7-1-2009
Abstract
The impact of chronic rhinosinusitis (CRS) on the olfactory mucosa (OM) is dramatic. Cellular profiles and epithelial integrity in OM biopsies were evaluated using histological and immunohistochemical methods to define a strategy for future histological studies of CRS. We have examined nasal biopsies of 54 CRS patients (18-63 years old) and have defined specific histopathological patterns of the OM: normal pseudostratified, goblet cell hyperplasia, squamous metaplasia, and erosion. Goblet cell hyperplasia was most similar to a normal pseudostratified OM pattern but with goblet cells intermixed in the apical layers. Squamous metaplasia exhibited an absence of olfactory supporting cells and had olfactory sensory neurons that were morphologically abnormal. It is unknown if these neurons would be functional in this type of tissue transformation. The pattern of erosion exhibited a severe loss of epithelial layers and a higher prevalence of infiltrating inflammatory cells within the olfactory epithelium when compared to the other OM patterns. Although it is not known if the OM patterns we have noted correspond to specific stages or distinct pathways of the disease, the template proposed here can be used in further studies to understand how the histopathological progression of CRS relates to olfactory loss and the response to treatment.
Volume
1170
First Page
590
Last Page
595
ISSN
1749-6632
Published In/Presented At
Yee, K. K., Pribitkin, E. A., Cowart, B. J., Rosen, D., Feng, P., & Rawson, N. E. (2009). Analysis of the olfactory mucosa in chronic rhinosinusitis. Annals of the New York Academy of Sciences, 1170, 590–595. https://doi.org/10.1111/j.1749-6632.2009.04364.x
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
19686198
Department(s)
Administration and Leadership
Document Type
Article