Smoking-associated squamous metaplasia in olfactory mucosa of patients with chronic rhinosinusitis.
Publication/Presentation Date
8-1-2009
Abstract
Few studies have examined the induction of squamous metaplasia in human olfactory nasal tissue caused by tobacco use and the implications it may have for olfaction, particularly when there are pre-existing insults, such as chronic rhinosinusitis (CRS). Quantitative histopathological analyses were performed on Alcian blue- and H&E-stained sections of nasal biopsies taken from the upper aspect of the middle turbinate of CRS patients. Chronic rhinosinusitis patients who were current smokers had a predominance of squamous metaplasia in the olfactory sensory epithelium, whereas CRS patients who were nonsmokers and were not exposed to secondhand cigarette smoke had a prevalence of goblet cell hyperplasia. In spite of this difference, the groups did not differ significantly in olfactory threshold sensitivity. The impact of primary cigarette smoke on olfaction and a possible role of squamous metaplasia in preserving olfactory neurogenesis are discussed.
Volume
37
Issue
5
First Page
594
Last Page
598
ISSN
1533-1601
Published In/Presented At
Yee, K. K., Pribitkin, E. A., Cowart, B. J., Vainius, A. A., Klock, C. T., Rosen, D., Hahn, C. G., & Rawson, N. E. (2009). Smoking-associated squamous metaplasia in olfactory mucosa of patients with chronic rhinosinusitis. Toxicologic pathology, 37(5), 594–598. https://doi.org/10.1177/0192623309338055
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
19487255
Department(s)
Administration and Leadership
Document Type
Article