Treatment-related morbidity in patients treated for sinonasal malignancy.

Authors

• Jena Patel
• Chandala Chitguppi
• Swar Vimawala
• Gregory Epps
• Judd Fastenberg
• James Evans
• Mindy Rabinowitz
• Marc Rosen
• Gurston Nyquist

Publication/Presentation Date

4-1-2020

Abstract

BACKGROUND: Sinonasal malignancies are a rare, heterogeneous group of tumors that often present at an advanced stage and require multimodal therapy. The presence of high-grade toxicity and sinonasal complications after treatment can negatively impact quality of life. In this study we aim to describe posttreatment morbidity in patients with sinonasal malignancy.

METHODS: A retrospective analysis of all patients treated for sinonasal malignancy was conducted from 2005 to 2018 at a tertiary referral institution. A total of 129 patients met the inclusion criteria. Primary outcomes were treatment details, pathology, posttreatment complications, and radiation toxicity. Fisher's exact test, chi-square test, and Student t test were used for statistical analysis.

RESULTS: Mean age was 58.4 (median, 61; range, 19-94) years. After diagnosis, 24 patients had surgery alone, 46 had surgery with radiation alone, 47 had surgery with chemoradiation, and 14 received definitive chemoradiation. Overall, 10.4% (n = 12) of patients had postoperative complications, and 21.0% (n = 22) had high-grade (grade 3-5) radiation toxicity. After radiation, 20% (n = 21) of patients had chronic sinusitis requiring functional endoscopic sinus surgery and 20% (n = 21) had symptomatic nasal obstruction requiring operative debridement.

CONCLUSION: Sinonasal complications, including nasal obstruction and chronic sinusitis, occur frequently after definitive treatment of sinonasal malignancy and should be addressed when considering quality of life in survivors. These complications occur more frequently in patients who undergo chemoradiation as opposed to surgery alone.

Volume

10

Issue

4

First Page

526

Last Page

532

ISSN

2042-6984

Published In/Presented At

Patel, J., Chitguppi, C., Vimawala, S., Epps, G., Fastenberg, J., Evans, J., Rabinowitz, M., Rosen, M., & Nyquist, G. (2020). Treatment-related morbidity in patients treated for sinonasal malignancy. International forum of allergy & rhinology, 10(4), 526–532. https://doi.org/10.1002/alr.22509

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

31930702

Department(s)

Administration and Leadership

Document Type

Article