The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo.

Authors

• M Resnicoff
• D Abraham
• W Yutanawiboonchai
• H L Rotman
• J Kajstura
• R Rubin
• P Zoltick
• R Baserga

Publication/Presentation Date

6-1-1995

Abstract

The role of the insulin-like growth factor I receptor (IGF-IR) in programmed cell death has been investigated in vivo in a biodiffusion chamber, where the extent of cell death could be determined quantitatively. We found that a decrease in the number of IGF-IRs causes massive apoptosis in vivo in several transplantable tumors, either from humans or rodents. Conversely, an overexpressed IGF-IR protects cells from apoptosis in vivo. We also show that the same conditions that in vitro cause only partial growth arrest with a minimum of cell death, induce in vivo almost complete cell death. We conclude that the IGF-IR activated by its ligands plays a very important protective role in programmed cell death, and that its protective action is even more striking in vivo than in vitro.

Volume

55

Issue

11

First Page

2463

Last Page

2469

ISSN

0008-5472

Published In/Presented At

Resnicoff, M., Abraham, D., Yutanawiboonchai, W., Rotman, H. L., Kajstura, J., Rubin, R., Zoltick, P., & Baserga, R. (1995). The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo. Cancer research, 55(11), 2463–2469.

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

7758000

Department(s)

Administration and Leadership

Document Type

Article