Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor I receptors.
Publication/Presentation Date
9-1-1995
Abstract
We have investigated whether there is a quantitative relationship between the insulin-like growth factor I receptor (IGF-IR), the extent of apoptosis in vivo, and tumorigenesis. C6 rat glioblastoma cells were treated with increasing concentrations of antisense oligodeoxynucleotides to the IGF-IR RNA. The extent of apoptosis in vivo is correlated to the decrease in IGF-IR levels and, in turn, tumorigenesis in nude mice is correlated to the fraction of surviving cells. In syngeneic rats, a host response leads to complete inhibition of tumorigenesis. These findings establish, for the first time on a quantitative basis, the relationship between IGF-IR levels and the extent of apoptosis, as well as the relationship between the initial apoptotic event and the time of appearance of transplantable tumors.
Volume
55
Issue
17
First Page
3739
Last Page
3741
ISSN
0008-5472
Published In/Presented At
Resnicoff, M., Burgaud, J. L., Rotman, H. L., Abraham, D., & Baserga, R. (1995). Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor I receptors. Cancer research, 55(17), 3739–3741.
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
7641185
Department(s)
Administration and Leadership
Document Type
Article