Methylation of an immediate-early inducible gene as a mechanism for B cell tolerance induction.
Publication/Presentation Date
11-9-1990
Abstract
Stage-specific gene regulation is important in determining cell function during development. Immature B cells expressing membrane-bound immunoglobulin M (mIgM) are sensitive to antigen-induced tolerance, whereas mature B cells are activated by antigen. Previous studies have established an association between Egr-1 gene induction and antigen receptor (mIgM)-mediated activation of mature B cells. Here it is shown that the immature B cell line WEHI-231 and tolerance-sensitive bone marrow-derived B cells do not express Egr-1. It is further shown that lack of inducible expression in these cells is due to specific methylation of the Egr-1 gene. Thus, covalent inactivation of an activation-associated gene may explain tolerance sensitivity at specific stages of B cell development.
Volume
250
Issue
4982
First Page
797
Last Page
800
ISSN
0036-8075
Published In/Presented At
Seyfert, V. L., McMahon, S. B., Glenn, W. D., Yellen, A. J., Sukhatme, V. P., Cao, X. M., & Monroe, J. G. (1990). Methylation of an immediate-early inducible gene as a mechanism for B cell tolerance induction. Science (New York, N.Y.), 250(4982), 797–800. https://doi.org/10.1126/science.2237429
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
2237429
Department(s)
Administration and Leadership
Document Type
Article