Postnatal development of the wild-type and weaver cerebellum after embryonic administration of propylthiouracil (PTU).
Publication/Presentation Date
7-1-1990
Abstract
In this study we used propylthiouracil (PTU), a thyroid hormone-inhibiting compound, to render +/+, wv/+, and wv/wv embryos hypothyroid in order to test if the appearance of external granule layer (EGL) cell death in the weaver cerebellum is affected by alteration of granule cell development. At birth, the number of EGL cells in the PTU-treated cerebellum was reduced, compared to control animals, by 50%. Also, the amount of cell death was reduced in the PTU-treated wv/wv cerebellum. As adults, no differences were seen between PTU-treated and untreated mutant or normal cerebella. If the hypothyroid treatment that results in a 50% decrease in EGL cell number is due to an extension of cell cycling time, then the expression of the weaver phenotype of cell death likely follows granule cell exit from the cell cycle.
Volume
54
Issue
2
First Page
282
Last Page
286
ISSN
0165-3806
Published In/Presented At
Smeyne, R. J., & Goldowitz, D. (1990). Postnatal development of the wild-type and weaver cerebellum after embryonic administration of propylthiouracil (PTU). Brain research. Developmental brain research, 54(2), 282–286. https://doi.org/10.1016/0165-3806(90)90151-n
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
2397591
Department(s)
Administration and Leadership
Document Type
Article