Unlocking p53 response elements: DNA shape is the key.
Publication/Presentation Date
1-1-2021
Abstract
For recognition of specific regulatory sequences in the genome (i.e., response elements, REs), the tumor suppressor protein 53 kDa (p53) exhibits dose-dependent selectivity. In general, binding to REs linked to target genes involved in the positive regulation of cell death requires higher levels of p53 than those connected to cell survival. Our recent findings provide a mechanistic explanation for this phenomenon. Specifically, we demonstrate that subtle differences in DNA shape, encoded in RE DNA sequence, determine the utilization of two biochemically distinct DNA-binding modes, ultimately connected to different biological outcomes.
Volume
8
Issue
3
First Page
1905489
Last Page
1905489
ISSN
2372-3556
Published In/Presented At
Farkas, M., & McMahon, S. (2021). Unlocking p53 response elements: DNA shape is the key. Molecular & cellular oncology, 8(3), 1905489. https://doi.org/10.1080/23723556.2021.1905489
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
34027043
Department(s)
Administration and Leadership
Document Type
Article