Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates.

Authors

• Marina Farkas
• Hideharu Hashimoto
• Yingtao Bi
• Ramana V Davuluri
• Lois Resnick-Silverman
• James J Manfredi
• Erik W Debler
• Steven B McMahon

Publication/Presentation Date

1-20-2021

Abstract

The tumor suppressor p53 integrates stress response pathways by selectively engaging one of several potential transcriptomes, thereby triggering cell fate decisions (e.g., cell cycle arrest, apoptosis). Foundational to this process is the binding of tetrameric p53 to 20-bp response elements (REs) in the genome (RRRCWWGYYYN

Volume

12

Issue

1

First Page

484

Last Page

484

ISSN

2041-1723

Published In/Presented At

Farkas, M., Hashimoto, H., Bi, Y., Davuluri, R. V., Resnick-Silverman, L., Manfredi, J. J., Debler, E. W., & McMahon, S. B. (2021). Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates. Nature communications, 12(1), 484. https://doi.org/10.1038/s41467-020-20783-z

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

33473123

Department(s)

Administration and Leadership

Document Type

Article