Therapeutic targeting of gastrointestinal cancer stem cells.

Authors

• Jonathan Stem
• John C Flickinger
• Dante Merlino
• Ellen M Caparosa
• Adam E Snook
• Scott A Waldman

Publication/Presentation Date

5-1-2019

Abstract

Gastrointestinal cancers remain a tremendous burden on society. Despite advances in therapy options, including chemotherapy and radiation, cancer mortality from recurrences and metastases occur frequently. Cancer stem cells (CSCs) drive disease recurrence and metastasis, as these cells are uniquely equipped to self-renew and evade therapy. Therefore, cancer eradication requires treatment strategies that target CSCs in addition to differentiated cancer cells. This review highlights current literature on therapies targeting CSCs in gastrointestinal cancer.

Volume

14

Issue

4

First Page

331

Last Page

343

ISSN

1746-076X

Published In/Presented At

Stem, J., Flickinger, J. C., Jr, Merlino, D., Caparosa, E. M., Snook, A. E., & Waldman, S. A. (2019). Therapeutic targeting of gastrointestinal cancer stem cells. Regenerative medicine, 14(4), 331–343. https://doi.org/10.2217/rme-2018-0146

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

31025613

Department(s)

Administration and Leadership

Document Type

Article