A promoter that drives transgene expression in cerebellar Purkinje and retinal bipolar neurons.
Publication/Presentation Date
4-13-1990
Abstract
A genomic clone encoding the Purkinje cell-specific L7 protein has been isolated and utilized to drive the expression of beta-galactosidase in mice. Three independent transgenic lines, germ line transformed with an L7-beta-galactosidase fusion gene, exhibit beta-galactosidase expression in both cerebellar Purkinje cells and retinal bipolar neurons. This distribution is the same as that previously determined for the L7 protein by immunohistochemistry. The transgenic murine lines can be used to obtain populations of marked Purkinje and bipolar neurons. Similar L7 promoter constructs can be used to express other foreign genes specifically in these two classes of neurons.
Volume
248
Issue
4952
First Page
223
Last Page
226
ISSN
0036-8075
Published In/Presented At
Oberdick, J., Smeyne, R. J., Mann, J. R., Zackson, S., & Morgan, J. I. (1990). A promoter that drives transgene expression in cerebellar Purkinje and retinal bipolar neurons. Science (New York, N.Y.), 248(4952), 223–226. https://doi.org/10.1126/science.2109351
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
2109351
Department(s)
Administration and Leadership
Document Type
Article