Early myelin lesions in experimental allergic neuritis.
Publication/Presentation Date
7-1-1990
Abstract
We examined the evolution of demyelination in spinal roots of Lewis rats immunized with whole nerve and complete Freund's adjuvant. Roots were morphologically normal until 11 days after immunization, when we found endoneurial edema and myelin vesiculation in the absence of mononuclear cell contacts. Macrophage-associated myelin stripping was not detected until day 12. Macrophage infiltrations were extensive by day 14, but lymphocytes were sparse. These observations indicate that in experimental allergic neuritis, myelin injury may occur before macrophage-mediated demyelination, and provide support for an early role of serum factors in the development of this disorder.
Volume
13
Issue
7
First Page
629
Last Page
636
ISSN
0148-639X
Published In/Presented At
Rosen, J. L., Brown, M. J., Hickey, W. F., & Rostami, A. (1990). Early myelin lesions in experimental allergic neuritis. Muscle & nerve, 13(7), 629–636. https://doi.org/10.1002/mus.880130712
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
2388663
Department(s)
Administration and Leadership
Document Type
Article