Effect of experimental allergic neuritis serum on normal rat peripheral nerve.

Authors

• J L Rosen
• M J Brown
• A Rostami

Publication/Presentation Date

1-1-1990

Abstract

To study the possible in vivo activity of experimental allergic neuritis (EAN) serum, we injected serum from rats immunized with whole nerve, P2 protein or adjuvant alone into the sciatic nerve of normal Lewis rats. Serum from whole nerve and P2-immunized animals produced demyelination 24 h after injection. Only high-titer anti-P2 serum was active and no control serum had this effect. Anti-P2 antibodies or other serum factors may contribute to the pathogenesis of whole nerve and P2-induced EAN.

Volume

58

Issue

2

First Page

95

Last Page

98

ISSN

1015-2008

Published In/Presented At

Rosen, J. L., Brown, M. J., & Rostami, A. (1990). Effect of experimental allergic neuritis serum on normal rat peripheral nerve. Pathobiology : journal of immunopathology, molecular and cellular biology, 58(2), 95–98. https://doi.org/10.1159/000163570

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

1694436

Department(s)

Administration and Leadership

Document Type

Article