Peptide 53-78 of myelin P2 protein is a T cell epitope for the induction of experimental autoimmune neuritis.
Publication/Presentation Date
2-1-1991
Abstract
We have recently described the clinical and pathological features of experimental autoimmune neuritis (EAN) in Lewis rats inoculated with varying doses of a synthetic peptide corresponding to the amino acid residues 53-78 of bovine P2 protein (SP-26). Immunization with this synthetic peptide was able to induce severe clinical and pathological characteristics of EAN. We are now reporting that, SP-26 T cell lines derived from spleen and lymph node cell populations of such immunized rats, upon being triggered by SP-26, can adoptively transfer severe clinical and histological signs of EAN to naive syngeneic recipients. The disease appears 7-8 days postinoculation of the cells and persist 5-10 days. The pathological features were indistinguishable from SP-26-induced active EAN which appears 12-15 days after sensitization. Examination of the surface phenotype of the cells that were used for the passive transfer of EAN by FACS analysis, showed majority of the cells to be CD4+, Ia+ cells.
Volume
132
Issue
2
First Page
433
Last Page
441
ISSN
0008-8749
Published In/Presented At
Rostami, A., & Gregorian, S. K. (1991). Peptide 53-78 of myelin P2 protein is a T cell epitope for the induction of experimental autoimmune neuritis. Cellular immunology, 132(2), 433–441. https://doi.org/10.1016/0008-8749(91)90040-i
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
1703049
Department(s)
Administration and Leadership
Document Type
Article