Factors Associated with Retinal Detachment after Pediatric Cataract Surgery in the IRIS® Registry.
Publication/Presentation Date
8-1-2025
Abstract
PURPOSE: This study leverages the American Academy of Ophthalmology's IRIS® Registry (Intelligent Research in Sight) to identify factors associated with retinal detachment (RD) after pediatric cataract surgery.
DESIGN: Retrospective cohort study.
PARTICIPANTS: All children (age < 18 years) who underwent cataract surgery between January 2013 and December 2020 at practices that participate in the IRIS Registry.
METHODS: Data collected included patient demographics and medical history. Current Procedural Terminology codes were used to identify procedures for cataract surgery and RD repair. International Classification of Disease codes were used to classify diagnoses such as degenerative high myopia, persistent fetal vasculature, retinopathy of prematurity, ocular trauma, and retinal detachment. The Kaplan-Meier estimator was used to determine the cumulative incidence of retinal detachment diagnosis and repair after cataract surgery. Hazard ratios with 95% confidence intervals were calculated using multivariable Cox regression models.
MAIN OUTCOME MEASURES: Cumulative incidence of RD diagnosis and repair within 5 years of cataract surgery.
RESULTS: Seven thousand four hundred seven children (53% male, 49% White non-Hispanic) were identified and included. The cumulative incidence of retinal detachment diagnosis and repair after cataract surgery was 3.8% (95% CI, 3.1%-4.5%) and 1.6% (95% CI, 1.2%-2.0%), respectively. Children with a history of ocular trauma (hazard ratio [HR], 2.22; 95% CI 1.39-3.57; P < 0.001), aphakia (HR, 2.10; 95% CI, 1.43-3.10; P < 0.001), premature retina (HR 2.73; 95% CI, 1.36-5.48; P = 0.005), persistent fetal vasculature (HR, 3.26; 95% CI, 1.58-6.71; P = 0.001), and Hispanic ethnicity (HR, 1.71; 95% CI, 1.15-2.54; P = 0.008) were at increased risk of RD diagnosis within 5 years of cataract surgery. Similar risk factors were identified for RD requiring surgical repair.
CONCLUSIONS: Among children undergoing cataract surgery in the IRIS Registry, RD was associated with a history of ocular trauma, aphakia, premature retina, persistent fetal vasculature, and Hispanic ethnicity. Identifying risk factors for complications after cataract surgery is essential to guide preoperative decision-making and long-term monitoring to mitigate RD risk in vulnerable patients.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
Volume
132
Issue
8
First Page
888
Last Page
894
ISSN
1549-4713
Published In/Presented At
Altamirano, F., Jeon, J. H., Lee, J. Y., Elze, T., Miller, J. W., Lorch, A. C., VanderVeen, D. K., Gonzalez, E., Oke, I., & IRIS® Registry Analytic Center Consortium (2025). Factors Associated with Retinal Detachment after Pediatric Cataract Surgery in the IRIS® Registry. Ophthalmology, 132(8), 888–894. https://doi.org/10.1016/j.ophtha.2025.03.003
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
40081617
Department(s)
Administration and Leadership
Document Type
Article