Effects of atriopeptins on relaxation and cyclic GMP levels in rat and rabbit aortas.
Publication/Presentation Date
1-14-1986
Abstract
The effects of atriopeptins I and II on relaxation and cyclic GMP levels were studied on rat and rabbit aortas. Atriopeptin I was 2- and 100-fold less potent than atriopeptin II in causing relaxation of rat and rabbit aortas, respectively. The atriopeptin-elevated cyclic GMP levels generally correlated with the amount of relaxation. These results demonstrate that the vasodilator profile and, presumably, the receptor for atrial natriuretic factor, varies among different blood vessels and species.
Volume
120
Issue
1
First Page
123
Last Page
126
ISSN
0014-2999
Published In/Presented At
Rapoport, R. M., Winquist, R. J., Baskin, E. P., Faison, E. P., Waldman, S. A., & Murad, F. (1986). Effects of atriopeptins on relaxation and cyclic GMP levels in rat and rabbit aortas. European journal of pharmacology, 120(1), 123–126. https://doi.org/10.1016/0014-2999(86)90651-5
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
3004998
Department(s)
Administration and Leadership
Document Type
Article