Naloxone: analeptic action unrelated to opiate receptor antagonism?
Publication/Presentation Date
4-1-1982
Abstract
The effects on the duration of sleeping time (ST) of the opiate receptor antagonists, naloxone and naltrexone, were determined in rats anesthetized by intraperitoneal injection of ketamine, halothane, or pentobarbital. Intracerebroventricular administration of naloxone shortened the duration of sleeping time induced by all three anesthetic agents in a dose-related manner. Centrally administered naltrexone (240 microgram) and systemically administered naloxone (50 mg/kg) prolonged the duration of pentobarbital sleeping time without altering duration of ketamine or halothane sleeping time. Naltrexone (120 microgram) had no effect on the duration of ST. This study does not support a role for opiate receptor regulation of the duration of sleeping time. The evidence supports the hypothesis that naloxone may govern the duration of narcosis through the activation of an opposing arousal system in the CNS, unrelated to pharmacologic competition for opiate receptors.
Volume
56
Issue
4
First Page
251
Last Page
253
ISSN
0003-3022
Published In/Presented At
Kraynack, B. J., & Gintautas, J. G. (1982). Naloxone: analeptic action unrelated to opiate receptor antagonism?. Anesthesiology, 56(4), 251–253.
Disciplines
Anesthesiology | Medicine and Health Sciences
PubMedID
6121523
Department(s)
Department of Anesthesiology
Document Type
Article