Reversal of procaine conduction blockade by adenine nucleotides in vivo and in vitro.
Publication/Presentation Date
8-1-1982
Abstract
The effect of the adenine nucleotides on procaine-induced conduction block in rats was investigated in vivo and in vitro. Both adenine and cyclic nucleotides significantly shortened the duration of sciatic nerve blocks in rats without affecting the frequency, degree of block or time of onset. Adenosine 5'-triphosphate (ATP) and N6, O2' dibutyryl 3':5'-monophosphate (db-cyclic AMP) were most effective. In isolated sciatic nerve preparations, the adenine nucleotides (ATP, adenosine 5'diphosphate (ADP), adenosine 5'monophosphate (AMP)) rapidly reversed procaine-induced depression of the action potential. These results suggest that local anesthetic effects may be mediated through interference with the physiological functions of the nucleotides.
Volume
26
Issue
4
First Page
334
Last Page
336
ISSN
0001-5172
Published In/Presented At
Kraynack, B. J., & Gintautas, J. (1982). Reversal of procaine conduction blockade by adenine nucleotides in vivo and in vitro. Acta anaesthesiologica Scandinavica, 26(4), 334–336. https://doi.org/10.1111/j.1399-6576.1982.tb01777.x
Disciplines
Anesthesiology | Medicine and Health Sciences
PubMedID
6981912
Department(s)
Department of Anesthesiology
Document Type
Article