Regulation, targets and functions of CSK.
Publication/Presentation Date
1-1-2023
Abstract
The Src family kinases (SFK) plays an important role in multiple signal transduction pathways. Aberrant activation of SFKs leads to diseases such as cancer, blood disorders, and bone pathologies. By phosphorylating and inactivating SFKs, the C-terminal Src kinase (CSK) serves as the key negative regulator of SFKs. Similar to Src, CSK is composed of SH3, SH2, and a catalytic kinase domain. However, while the Src kinase domain is intrinsically active, the CSK kinase domain is intrinsically inactive. Multiple lines of evidence indicate that CSK is involved in various physiological processes including DNA repair, permeability of intestinal epithelial cells (IECs), synaptic activity, astrocyte-to-neuron communication, erythropoiesis, platelet homeostasis, mast cell activation, immune and inflammation responses. As a result, dysregulation of CSK may lead to many diseases with different underlying molecular mechanisms. Furthermore, recent findings suggest that in addition to the well-established CSK-SFK axis, novel CSK-related targets and modes of CSK regulation also exist. This review focuses on the recent progress in this field for an up-to-date understanding of CSK.
Volume
11
First Page
1206539
Last Page
1206539
ISSN
2296-634X
Published In/Presented At
Zhu, S., Wang, H., Ranjan, K., & Zhang, D. (2023). Regulation, targets and functions of CSK. Frontiers in cell and developmental biology, 11, 1206539. https://doi.org/10.3389/fcell.2023.1206539
Disciplines
Medicine and Health Sciences
PubMedID
37397251
Department(s)
Medical Education
Document Type
Article