Polarization of THP-1-Derived Human M0 to M1 Macrophages Exposed to Flavored E-Liquids.

Authors

Raivat Shah
Emily D Luo
Carly A Shaffer
Maya Tabakha
Sophie Tomov
Siara H Minton
Mikaela K Brown
Dominic L Palazzolo
Giancarlo A Cuadra

Publication/Presentation Date

5-29-2025

Abstract

Electronic cigarettes (ECIGs) are widely used but their effects on the immune system need to be further investigated. Macrophages are white blood cells central to the immune response. Using THP-1-derived M0 macrophages, this study aims to determine the effects of ECIG liquids (E-liquids) on the polarization of M0 to the pro-inflammatory M1 macrophage subtype. THP-1 cells were cultured and differentiated to M0 macrophages using RPMI media. E-liquids ± cinnamon, menthol, strawberry and tobacco flavors were added to cell cultures at 1% (

Volume

13

Issue

6

ISSN

2305-6304

Published In/Presented At

Shah, R., Luo, E. D., Shaffer, C. A., Tabakha, M., Tomov, S., Minton, S. H., Brown, M. K., Palazzolo, D. L., & Cuadra, G. A. (2025). Polarization of THP-1-Derived Human M0 to M1 Macrophages Exposed to Flavored E-Liquids. Toxics, 13(6), 451. https://doi.org/10.3390/toxics13060451

Disciplines

Education | Medical Education

PubMedID

40559924

Department(s)

Department of Education

Document Type

Article