Intraventricular Pressure and Volume during Conventional and Automated Head-up CPR.
Publication/Presentation Date
2-17-2025
Abstract
BACKGROUND: Active compression-decompression (ACD) CPR, an impedance threshold device (ITD) and automated head and thorax elevation, collectively termed AHUP-CPR, increases cerebral and coronary perfusion pressures, brain blood flow, end-tidal CO2 (ETCO2) and cerebral oximetry (rSO2) in animal models compared with conventional (C) CPR. We tested the hypothesis that cardiac stroke volume (SV) is higher with AHUP-CPR versus C-CPR or ACD+ITD in a porcine cardiac arrest model.
METHODS: Farm pigs (n=14) were sedated, anesthetized, and ventilated. Hemodynamics, including biventricular pressure-volume loops, were continuously measured. Following 10 minutes of untreated ventricular fibrillation, C-CPR was performed for 2 minutes, then ACD+ITD for 2 minutes in the flat position, then AHUP-CPR thereafter. Linear mixed-effects model and Pearson correlation comparisons were used for statistical analysis.
RESULTS: Coronary and cerebral perfusion pressures, ETCO2, rSO2, and right (RV) and left (LV) ventricular SV increased progressively and significantly with the implementation of AHUP-CPR (p
CONCLUSION: A fundamental and inherent shortcoming of C-CPR, limited cardiac stroke volume, and resultant forward flow, can be overcome with AHUP-CPR. These findings may help explain the better outcomes associated with early use of AHUP-CPR.
First Page
110551
Last Page
110551
ISSN
1873-1570
Published In/Presented At
Pourzand, P., Moore, J., Metzger, A., Suresh, M., Salverda, B., Hai, H., Duval, S., Bachista, K., Debaty, G., & Lurie, K. (2025). Intraventricular Pressure and Volume during Conventional and Automated Head-up CPR. Resuscitation, 110551. Advance online publication. https://doi.org/10.1016/j.resuscitation.2025.110551
Disciplines
Medicine and Health Sciences
PubMedID
39970974
Department(s)
Department of Emergency Medicine Residents, Fellows and Residents
Document Type
Article
