Cryoneurolysis for phantom limb pain: a systematic review.
Publication/Presentation Date
12-1-2024
Abstract
AIMS: Phantom limb pain (PLP) is a painful sensation occurring in patients around the site of an amputation. The aim of this systematic review is to evaluate the efficacy of cryoneurolysis in the management of phantom limb pain.
MATERIALS AND METHODS: A systematic review was performed according to the PRISMA 2020 guidelines. An initial search yielded 200 articles from four major scientific databases (PubMed, Embase, Cochrane Library, WebOfScience). Five articles met inclusion criteria, four of which underwent additional pooled statistical analysis.
RESULTS: Pooled analysis of the included trials revealed a cumulative Cohen's d effect size of 1.55 (95% CI [0.24, 2.87];
CONCLUSIONS: The large effect size demonstrated a statistically and clinically significant improvement in patient-reported pain. Additionally, patients may be able to reduce their amount of pharmaceutical pain management with successful cryoneurolysis treatment. However, these findings are limited by the small sample size and high heterogeneity between studies. Further high-quality studies should be performed to corroborate these findings.
PROTOCOL REGISTRATION: www.crd.york.ac.uk/prospero identifier is CRD42024543085.
Volume
14
Issue
12
First Page
673
Last Page
680
ISSN
1758-1877
Published In/Presented At
Brancaccio, H., Goodwin, B., DesRochers, J., Birnbaum, A., Cagatay, U., Koutsenko, B., Flatley, C., & Siu, G. (2024). Cryoneurolysis for phantom limb pain: a systematic review. Pain management, 14(12), 673–680. https://doi.org/10.1080/17581869.2024.2441650
Disciplines
Medicine and Health Sciences
PubMedID
39707720
Department(s)
Fellows and Residents
Document Type
Article
