Endothelin-1-induced endothelial microvesicles impair endothelial cell function.

Authors

L Madden Brewster
Vinicius P Garcia
Ma'ayan V Levy
Kelly A Stockelman
Anabel Goulding
Noah M DeSouza
Jared J Greiner
Jamie G Hijmans
Christopher A DeSouza

Publication/Presentation Date

6-1-2020

Abstract

The aim of this study was to determine the effects of endothelin-1 (ET-1)-generated endothelial microvesicles (EMVs) on endothelial cell inflammation, apoptosis, and endothelial nitric oxide synthase (eNOS). Human umbilical vein endothelial cells (HUVECs) were treated with ET-1 for 24 h. EMVs released into the supernatant from cells treated with ET-1 or vehicle were isolated and quantified. EMV release was higher (

Volume

128

Issue

6

First Page

1497

Last Page

1505

ISSN

1522-1601

Published In/Presented At

Brewster, L. M., Garcia, V. P., Levy, M. V., Stockelman, K. A., Goulding, A., DeSouza, N. M., Greiner, J. J., Hijmans, J. G., & DeSouza, C. A. (2020). Endothelin-1-induced endothelial microvesicles impair endothelial cell function. Journal of applied physiology (Bethesda, Md. : 1985), 128(6), 1497–1505. https://doi.org/10.1152/japplphysiol.00816.2019

Disciplines

Medicine and Health Sciences

PubMedID

32324474

Department(s)

Fellows and Residents

Document Type

Article