The Role of Glutathione in Prevention of COVID-19 Immunothrombosis: A Review.
Publication/Presentation Date
3-20-2023
Abstract
Immunothrombosis has emerged as a dominant pathological process exacerbating morbidity and mortality in acute- and long-COVID-19 infections. The hypercoagulable state is due in part to immune system dysregulation, inflammation and endothelial cell damage, as well as a reduction in defense systems. One defense mechanism in particular is glutathione (GSH), a ubiquitously found antioxidant. Evidence suggests that reduction in GSH increases viral replication, pro-inflammatory cytokine release, and thrombosis, as well as decreases macrophage-mediated fibrin removal. The collection of adverse effects as a result of GSH depletion in states like COVID-19 suggest that GSH depletion is a dominant mechanism of immunothrombosis cascade. We aim to review the current literature on the influence of GSH on COVID-19 immunothrombosis pathogenesis, as well as the beneficial effects of GSH as a novel therapeutic for acute- and long-COVID-19.
Volume
28
Issue
3
First Page
59
Last Page
59
ISSN
2768-6698
Published In/Presented At
Glassman, I., Le, N., Mirhosseini, M., Alcantara, C. A., Asif, A., Goulding, A., Muneer, S., Singh, M., Robison, J., Guilford, F., & Venketaraman, V. (2023). The Role of Glutathione in Prevention of COVID-19 Immunothrombosis: A Review. Frontiers in bioscience (Landmark edition), 28(3), 59. https://doi.org/10.31083/j.fbl2803059
Disciplines
Medicine and Health Sciences
PubMedID
37005767
Department(s)
Fellows and Residents
Document Type
Article