Association of miR-499 Polymorphism and Its Regulatory Networks with Hashimoto Thyroiditis Susceptibility: A Population-Based Case-Control Study.
Publication/Presentation Date
9-18-2021
Abstract
Hashimoto thyroiditis (HT) is a common autoimmune disorder with a strong genetic background. Several genetic factors have been suggested, yet numerous genetic contributors remain to be fully understood in HT pathogenesis. MicroRNAs (miRs) are gene expression regulators critically involved in biological processes, of which polymorphisms can alter their function, leading to pathologic conditions, including autoimmune diseases. We examined whether miR-499 rs3746444 polymorphism is associated with susceptibility to HT in an Iranian subpopulation. Furthermore, we investigated the potential interacting regulatory network of the miR-499. This case-control study included 150 HT patients and 152 healthy subjects. Genotyping of rs3746444 was performed by the PCR-RFLP method. Also, target genomic sites of the polymorphism were predicted using bioinformatics. Our results showed that miR-499 rs3746444 was positively associated with HT risk in heterozygous (OR = 3.32, 95%CI = 2.00-5.53,
Volume
22
Issue
18
ISSN
1422-0067
Published In/Presented At
Tabasi, F., Hasanpour, V., Sarhadi, S., Kaykhaei, M. A., Pourzand, P., Heravi, M., Langari, A. A., Bahari, G., Taheri, M., Hashemi, M., & Ghavami, S. (2021). Association of miR-499 Polymorphism and Its Regulatory Networks with Hashimoto Thyroiditis Susceptibility: A Population-Based Case-Control Study. International journal of molecular sciences, 22(18), 10094. https://doi.org/10.3390/ijms221810094
Disciplines
Medicine and Health Sciences
PubMedID
34576267
Department(s)
Fellows and Residents
Document Type
Article