The Reticulon-4 3-bp Deletion/Insertion Polymorphism Is Associated with Structural mRNA Changes and the Risk of Breast Cancer: A Population-Based Case-Control Study with Bioinformatics Analysis.
Publication/Presentation Date
7-12-2023
Abstract
Breast cancer (BC) is a complex disease caused by molecular events that disrupt cellular survival and death. Discovering novel biomarkers is still required to better understand and treat BC. The reticulon-4 (RTN4) gene, encoding Nogo proteins, plays a critical role in apoptosis and cancer development, with genetic variations affecting its function. We investigated the rs34917480 in RTN4 and its association with BC risk in an Iranian population sample. We also predicted the rs34917480 effect on RTN4 mRNA structure and explored the RTN4's protein-protein interaction network (PPIN) and related pathways. In this case-control study, 437 women (212 BC and 225 healthy) were recruited. The rs34917480 was genotyped using AS-PCR, mRNA secondary structure was predicted with RNAfold, and PPIN was constructed using the STRING database. Our findings revealed that this variant was associated with a decreased risk of BC in heterozygous (
Volume
13
Issue
7
ISSN
2075-1729
Published In/Presented At
Pourzand, P., Tabasi, F., Fayazbakhsh, F., Sarhadi, S., Bahari, G., Mohammadi, M., Jomepour, S., Nafeli, M., Mosayebi, F., Heravi, M., Taheri, M., Hashemi, M., & Ghavami, S. (2023). The Reticulon-4 3-bp Deletion/Insertion Polymorphism Is Associated with Structural mRNA Changes and the Risk of Breast Cancer: A Population-Based Case-Control Study with Bioinformatics Analysis. Life (Basel, Switzerland), 13(7), 1549. https://doi.org/10.3390/life13071549
Disciplines
Medicine and Health Sciences
PubMedID
37511924
Department(s)
Fellows and Residents
Document Type
Article