Precision Surgery Guided by Intraoperative Molecular Imaging.
Publication/Presentation Date
11-1-2022
Abstract
Intraoperative molecular imaging (IMI) has recently emerged as an important tool in the armamentarium of surgical oncologists. IMI allows real-time assessment of oncologic resection quality, margin assessment, and occult disease detection during real-time surgery. Numerous tracers have now been developed for use in IMI-guided tissue sampling. Fluorochromes localize to the tumor by taking advantage of their disorganized capillary milieu, overexpressed receptors, or upregulated enzymes. Although fluorescent tracers can suffer from issues of autofluorescence and lack of depth penetration, these challenges are being addressed through hybrid radioactive/fluorescent tracers and new tracers that fluoresce in the near-infrared (NIR-II [wavelength > 1,000 nm]) range. IMI is already being used to treat numerous cancers, with demonstrated improvement in cancer recurrence and patient outcomes without incurring significant burden on either clinicians or patients. In this comprehensive review, we discuss history, mechanism, current oncologic applications, and future directions of IMI-guided optical biopsy.
Volume
63
Issue
11
First Page
1620
Last Page
1627
ISSN
1535-5667
Published In/Presented At
Azari, F., Zhang, K., Kennedy, G. T., Chang, A., Nadeem, B., Delikatny, E. J., & Singhal, S. (2022). Precision Surgery Guided by Intraoperative Molecular Imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 63(11), 1620–1627. https://doi.org/10.2967/jnumed.121.263409
Disciplines
Medicine and Health Sciences
PubMedID
35953303
Department(s)
Fellows and Residents
Document Type
Article