Impact of type 2 diabetes mellitus on interstitial lung disease risk in rheumatoid arthritis.
Publication/Presentation Date
11-26-2025
Abstract
BACKGROUND: This study investigates the impact of type 2 diabetes mellitus (T2DM) on the risk of interstitial lung disease (ILD) and its subtypes in patients with rheumatoid arthritis (RA). RA is often complicated by ILD. T2DM has systemic proinflammatory effects, but its impact on RA-related ILD is unclear. This research aims to elucidate the interplay between these conditions to inform clinical management and patient care strategies.
AIM: To determine if RA patients with T2DM have a higher occurrence of ILD compared to RA patients without T2DM.
METHODS: We conducted a retrospective cohort study using the 2019-2020 National Inpatient Sample. Adult RA patients with and without T2DM were identified
RESULTS: Among 199380 RA inpatients, ILD was more common in those with T2DM (2.25%)
CONCLUSION: T2DM increases ILD risk in RA and is linked to higher rates of pulmonary hypertension and pneumothorax, suggesting a role in exacerbating RA-related lung complications.
Volume
13
Issue
33
First Page
110641
Last Page
110641
ISSN
2307-8960
Published In/Presented At
Sutton, J., Khattar, G., Saliba, F., Mourad, O., Aoun, L., Jdaidani, J., Qandil, H., Kaspar, C., Abu-Baker, S., Almardini, S., Haddadin, F., Bou Sanayeh, E., & Slobodnick, A. (2025). Impact of type 2 diabetes mellitus on interstitial lung disease risk in rheumatoid arthritis. World journal of clinical cases, 13(33), 110641. https://doi.org/10.12998/wjcc.v13.i33.110641
Disciplines
Medicine and Health Sciences
PubMedID
41356090
Department(s)
Fellows and Residents
Document Type
Article