The Changing Face of Osmotic Demyelination Syndrome: A Retrospective, Observational Cohort Study.

Publication/Presentation Date

8-1-2021

Abstract

OBJECTIVE: To describe the long-term outcomes of osmotic demyelination syndrome (ODS) in an updated cohort.

METHODS: We performed a retrospective medical records review of cases of ODS at the Massachusetts General and Brigham and Women's Hospitals using International Classification of Diseases-9th edition codes and a text-based search for

RESULTS: We identified 45 cases of ODS (mean age 48.4 years, range 0.07-75 years; 58% female patients). Common comorbidities included liver disease (27%, n = 12), alcoholism (44%, n = 20), and kidney failure (20%, n = 9). Twenty-nine percent of patients had a rapid correction of hyponatremia. Twenty-nine percent had other electrolyte abnormalities. Only 59% (24/41) of patients with complete electrolyte data had abnormalities that could explain their ODS. At the 6-month follow-up, 16% of the patients were dead and 60% of patients had minimal-to-no disability (mRS 0-2).

CONCLUSIONS: ODS has a diverse range of clinical presentations. Not all patients have electrolyte abnormalities. The prognosis is generally favorable, although 1 in 6 patients had died at 6 months, likely because of underlying disease states.

Volume

11

Issue

4

First Page

304

Last Page

310

ISSN

2163-0402

Disciplines

Medicine and Health Sciences

PubMedID

34484930

Department(s)

Department of Pediatrics

Document Type

Article

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