An international study presenting a federated learning AI platform for pediatric brain tumors.
Publication/Presentation Date
9-2-2024
Abstract
While multiple factors impact disease, artificial intelligence (AI) studies in medicine often use small, non-diverse patient cohorts due to data sharing and privacy issues. Federated learning (FL) has emerged as a solution, enabling training across hospitals without direct data sharing. Here, we present FL-PedBrain, an FL platform for pediatric posterior fossa brain tumors, and evaluate its performance on a diverse, realistic, multi-center cohort. Pediatric brain tumors were targeted due to the scarcity of such datasets, even in tertiary care hospitals. Our platform orchestrates federated training for joint tumor classification and segmentation across 19 international sites. FL-PedBrain exhibits less than a 1.5% decrease in classification and a 3% reduction in segmentation performance compared to centralized data training. FL boosts segmentation performance by 20 to 30% on three external, out-of-network sites. Finally, we explore the sources of data heterogeneity and examine FL robustness in real-world scenarios with data imbalances.
Volume
15
Issue
1
First Page
7615
Last Page
7615
ISSN
2041-1723
Published In/Presented At
Lee, E. H., Han, M., Wright, J., Kuwabara, M., Mevorach, J., Fu, G., Choudhury, O., Ratan, U., Zhang, M., Wagner, M. W., Goetti, R., Toescu, S., Perreault, S., Dogan, H., Altinmakas, E., Mohammadzadeh, M., Szymanski, K. A., Campen, C. J., Lai, H., Eghbal, A., … Yeom, K. W. (2024). An international study presenting a federated learning AI platform for pediatric brain tumors. Nature communications, 15(1), 7615. https://doi.org/10.1038/s41467-024-51172-5
Disciplines
Medicine and Health Sciences
PubMedID
39223133
Department(s)
Fellows and Residents
Document Type
Article