MRI Radiogenomics of Pediatric Medulloblastoma: A Multicenter Study.
Publication/Presentation Date
8-1-2022
Abstract
Background Radiogenomics of pediatric medulloblastoma (MB) offers an opportunity for MB risk stratification, which may aid therapeutic decision making, family counseling, and selection of patient groups suitable for targeted genetic analysis. Purpose To develop machine learning strategies that identify the four clinically significant MB molecular subgroups. Materials and Methods In this retrospective study, consecutive pediatric patients with newly diagnosed MB at MRI at 12 international pediatric sites between July 1997 and May 2020 were identified. There were 1800 features extracted from T2- and contrast-enhanced T1-weighted preoperative MRI scans. A two-stage sequential classifier was designed-one that first identifies non-wingless (
Volume
304
Issue
2
First Page
406
Last Page
416
ISSN
1527-1315
Published In/Presented At
Zhang, M., Wong, S. W., Wright, J. N., Wagner, M. W., Toescu, S., Han, M., Tam, L. T., Zhou, Q., Ahmadian, S. S., Shpanskaya, K., Lummus, S., Lai, H., Eghbal, A., Radmanesh, A., Nemelka, J., Harward, S., 2nd, Malinzak, M., Laughlin, S., Perreault, S., Braun, K. R. M., … Yeom, K. W. (2022). MRI Radiogenomics of Pediatric Medulloblastoma: A Multicenter Study. Radiology, 304(2), 406–416. https://doi.org/10.1148/radiol.212137
Disciplines
Medicine and Health Sciences
PubMedID
35438562
Department(s)
Fellows and Residents
Document Type
Article