Trends in incidence rates of hepatocellular carcinoma and stage at diagnosis by demographics in the U.S. from 2004 to 2021: a joinpoint analysis of the SEER database.
Publication/Presentation Date
2-19-2026
Abstract
OBJECTIVES: Hepatocellular carcinoma (HCC) is the 13th most common cancer in the U.S., causing approximately 30,000 deaths annually. Incidence has risen substantially over recent decades. This study examines trends in age-adjusted HCC incidence from 2004 to 2021.
MATERIALS AND METHODS: Incidence data for HCC (ICD-10 C22.0) from 2004 to 2021 were obtained from the Surveillance, Epidemiology and End Results (SEER) registry, representing 48% of the U.S. population. Rates were age-adjusted to the 2000 U.S. standard population and stratified by sex, race/ethnicity, age, and stage at diagnosis. Annual percentage changes (APCs) were calculated using Joinpoint regression with statistical significance set at
RESULTS AND CONCLUSION: From 2004 to 2015, overall HCC incidence increased (APC 3.16;
First Page
1
Last Page
9
ISSN
1502-7708
Published In/Presented At
Han, S., Mensah, B., Gaddipati, G., Singh, S., Varesiddy, R., Bilalaga, M. M., Atarere, J., Naqvi, H., & Haas, C. (2026). Trends in incidence rates of hepatocellular carcinoma and stage at diagnosis by demographics in the U.S. from 2004 to 2021: a joinpoint analysis of the SEER database. Scandinavian journal of gastroenterology, 1–9. Advance online publication. https://doi.org/10.1080/00365521.2026.2632060
Disciplines
Medicine and Health Sciences
PubMedID
41711476
Department(s)
Fellows and Residents
Document Type
Article