STAT3-mediated activation of
Publication/Presentation Date
11-28-2017
Abstract
Retinal neovascularization (RNV) is a sight threatening complication of ischemic retinopathies with limited therapeutic options. The transcription factor signal transducer and activator of transcription 3 (STAT3) has been shown to play a crucial role in promoting RNV. However, manipulating of STAT3 activity can cause significant adverse side effects due to its neurotrophic properties. In this study, we identified microRNA-21
Volume
8
Issue
61
First Page
103568
Last Page
103580
ISSN
1949-2553
Published In/Presented At
Gutsaeva, D. R., Thounaojam, M., Rajpurohit, S., Powell, F. L., Martin, P. M., Goei, S., Duncan, M., & Bartoli, M. (2017). STAT3-mediated activation of miR-21 is involved in down-regulation of TIMP3 and neovascularization in the ischemic retina. Oncotarget, 8(61), 103568–103580. https://doi.org/10.18632/oncotarget.21592
Disciplines
Medicine and Health Sciences
PubMedID
29262585
Department(s)
Fellows and Residents
Document Type
Article