Tranexamic acid can reduce blood loss and improve visibility in otological surgeries: a systematic review and meta-analysis of randomised controlled trials.

Publication/Presentation Date

12-1-2025

Abstract

OBJECTIVES: The objective of the study was to determine the effect of tranexamic acid in ear surgeries on duration of surgery, intra-operative blood loss, visibility and mean arterial pressure (MAP).

METHODS: A systematic review and meta-analysis were conducted following the 2020 PRISMA guidelines. Five databases were used (PubMed, Cochrane, Scopus, Web of Science and Embase). A search yielded 73 articles: 31 were duplicates and 42 were screened for by two authors. A standardised mean difference (SMD) was calculated to measure the effect size across studies.

RESULTS: The search yielded five final studies with ear procedures including tympanoplasty, atticotomy, mastoidectomy, ossiculoplasty, stapedotomy, tympanotomy and microscopic modified radical mastoidectomy. Tranexamic acid reduced duration of surgery (standardised mean difference = -3.82;

CONCLUSION: This meta-analysis demonstrated that tranexamic acid reduced bleeding and mean arterial pressure that were both statistically significant, while the reduction in duration of surgery was statistically insignificant. All studies reported better visibility.

Volume

139

Issue

12

First Page

1151

Last Page

1158

ISSN

1748-5460

Disciplines

Medicine and Health Sciences

PubMedID

41047571

Department(s)

Fellows and Residents

Document Type

Article

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