Inhibition of striatal indirect pathway during second postnatal week leads to long-lasting deficits in motivated behavior.
Publication/Presentation Date
3-1-2025
Abstract
Schizophrenia is a neuropsychiatric disorder with postulated neurodevelopmental etiology. Genetic and imaging studies have shown enhanced dopamine and D2 receptor occupancy in the striatum of patients with schizophrenia. However, whether alterations in postnatal striatal dopamine can lead to long-lasting changes in brain function and behavior is still unclear. Here, we approximated striatal D2R hyperfunction in mice via designer receptor-mediated activation of inhibitory Gi-protein signaling during a defined postnatal time window. We found that G
Volume
50
Issue
4
First Page
651
Last Page
661
ISSN
1740-634X
Published In/Presented At
Olivetti, P. R., Torres-Herraez, A., Gallo, M. E., Raudales, R., Sumerau, M., Moyles, S., Balsam, P. D., & Kellendonk, C. (2025). Inhibition of striatal indirect pathway during second postnatal week leads to long-lasting deficits in motivated behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 50(4), 651–661. https://doi.org/10.1038/s41386-024-01997-x
Disciplines
Medicine and Health Sciences
PubMedID
39327472
Department(s)
Fellows and Residents, Department of Family Medicine Residents
Document Type
Article