Differential microRNA-21 and microRNA-221 Upregulation in the Biventricular Failing Heart Reveals Distinct Stress Responses of Right Versus Left Ventricular Fibroblasts.
Publication/Presentation Date
1-1-2020
Abstract
BACKGROUND: The failing right ventricle (RV) does not respond like the left ventricle (LV) to guideline-directed medical therapy of heart failure, perhaps due to interventricular differences in their molecular pathophysiology.
METHODS: Using the canine tachypacing-induced biventricular heart failure (HF) model, we tested the hypothesis that interventricular differences in microRNAs (miRs) expression distinguish failing RV from failing LV.
RESULTS: Severe RV dysfunction was indicated by elevated end-diastolic pressure (11.3±2.5 versus 5.7±2.0 mm Hg;
CONCLUSIONS: We identified a novel, biological difference between RV and LV fibroblasts that might underlie distinctions in pathological remodeling of the RV in biventricular HF.
Volume
13
Issue
1
First Page
006426
Last Page
006426
ISSN
1941-3297
Published In/Presented At
Powers, J. C., Sabri, A., Al-Bataineh, D., Chotalia, D., Guo, X., Tsipenyuk, F., Berretta, R., Kavitha, P., Gopi, H., Houser, S. R., Khan, M., Tsai, E. J., & Recchia, F. A. (2020). Differential microRNA-21 and microRNA-221 Upregulation in the Biventricular Failing Heart Reveals Distinct Stress Responses of Right Versus Left Ventricular Fibroblasts. Circulation. Heart failure, 13(1), e006426. https://doi.org/10.1161/CIRCHEARTFAILURE.119.006426
Disciplines
Medicine and Health Sciences
PubMedID
31916447
Department(s)
Fellows and Residents
Document Type
Article