Stress fracture of bone under physiological multiaxial cyclic loading: Activity-based predictive models.
Publication/Presentation Date
1-1-2025
Abstract
While it is known that excessive accumulation of fatigue damage from daily activities contributes to fracture, a model of bone failure under physiologically relevant multiaxial cyclic loading needs to be developed in order to develop effective management strategies for stress or fatigue fractures. The role of strain-induced damage from repetitive loading is a strong candidate for such a model, as cycles of mechanical loading leading to failure can be measured directly. However, this approach has been limited by the restrictions of uniaxial loading models, which often overestimates the fatigue life of bone and suggests that bone will only break well beyond the realistic limits of exercise. To address this gap and develop a physiologically relevant model, our study leverages the power of four commonly used engineering failure criteria as a model for multiaxial loading using a cohort of human tibiae from cadaveric donors (age range 21-85 years old). Four failure criteria (Von Mises, Tsai-Wu, Findley critical plane, and maximum shear strain) were found to be effective in vitro models of tibial fracture when age groups of donors were combined (r
Volume
190
First Page
117279
Last Page
117279
ISSN
1873-2763
Published In/Presented At
George, W. T., Debopadhaya, S., Stephen, S. J., Botti, B. A., Burr, D. B., & Vashishth, D. (2025). Stress fracture of bone under physiological multiaxial cyclic loading: Activity-based predictive models. Bone, 190, 117279. https://doi.org/10.1016/j.bone.2024.117279
Disciplines
Medicine and Health Sciences
PubMedID
39393595
Department(s)
Fellows and Residents
Document Type
Article