Sex differences in glutamate AMPA receptor subunits mRNA with fast gating kinetics in the mouse cochlea.
Publication/Presentation Date
1-1-2023
Abstract
Evidence shows that females have increased supra-threshold peripheral auditory processing compared to males. This is indicated by larger auditory brainstem responses (ABR) wave I amplitude, which measures afferent spiral ganglion neuron (SGN)-auditory nerve synchrony. However, the underlying molecular mechanisms of this sex difference are mostly unknown. We sought to elucidate sex differences in ABR wave I amplitude by examining molecular markers known to affect synaptic transmission kinetics. Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) mediate fast excitatory transmission in mature SGN afferent synapses. Each AMPAR channel is a tetramer composed of GluA2, 3, and 4 subunits (
Volume
17
First Page
1100505
Last Page
1100505
ISSN
1662-5137
Published In/Presented At
Lozier, N. R., Muscio, S., Pal, I., Cai, H. M., & Rubio, M. E. (2023). Sex differences in glutamate AMPA receptor subunits mRNA with fast gating kinetics in the mouse cochlea. Frontiers in systems neuroscience, 17, 1100505. https://doi.org/10.3389/fnsys.2023.1100505
Disciplines
Medicine and Health Sciences
PubMedID
36936507
Department(s)
Fellows and Residents
Document Type
Article