Development of Bone Targeting Drugs.

Authors

Molly Stapleton
Kazuki Sawamoto
Carlos J Alméciga-Díaz
William G Mackenzie
Robert W Mason
Tadao Orii
Shunji Tomatsu

Publication/Presentation Date

6-23-2017

Abstract

The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage region. Targeting drugs to the site of action can not only increase efficacy but also reduce toxicity. Bone-targeting drugs are designed with either of two general targeting moieties, aimed at the entire skeletal system or a specific cell type. Most bone-targeting drugs utilize an affinity to hydroxyapatite, a major component of the bone matrix that includes a high concentration of positively-charged Ca

Volume

18

Issue

7

ISSN

1422-0067

Published In/Presented At

Stapleton, M., Sawamoto, K., Alméciga-Díaz, C. J., Mackenzie, W. G., Mason, R. W., Orii, T., & Tomatsu, S. (2017). Development of Bone Targeting Drugs. International journal of molecular sciences, 18(7), 1345. https://doi.org/10.3390/ijms18071345

Disciplines

Medicine and Health Sciences

PubMedID

28644392

Department(s)

Fellows and Residents

Document Type

Article