Heavy alcohol consumption attenuates human mesenteric artery responsiveness to sigma receptor-1 ligands.

Authors

• Patricia Zamora Diaz
• Tram Q Le
• Laura Hurtado Osorio
• Jenna F McQueen
• Charissa A Bloom
• Isabela Zimmermann Rollin
• Vishnu Venkitasubramony
• Laurelis E Santiago
• Mengmeng Chang
• Jerome W Breslin

Publication/Presentation Date

1-1-2026

Abstract

Sigma receptor agonists are suspected to modulate blood pressure in humans. We investigated how modulation of sigma receptors impacts phenylephrine (PE)-induced contraction in human mesenteric arterial rings obtained from human organ donors. This study also explored the relationship between sigma receptor activation, PE-induced arterial contraction, and the history of the organ donor's alcohol use. The concentration responsiveness of PE-induced arterial contraction was tested using wire myography in the absence and presence of the sigma receptor agonist PRE-084, and the sigma receptor antagonists BD-1047 and SM-21. Sigma receptor-1 expression in the arteries was also investigated using an automated capillary electrophoresis system. The results show that PRE-084 elicited a downward shift in the PE concentration-response curve. Notably, this trend only occurred in arteries from donors with histories of non-/light drinking or moderate drinking (

Volume

330

Issue

1

First Page

200

Last Page

200

ISSN

1522-1539

Published In/Presented At

Zamora Diaz, P., Le, T. Q., Hurtado Osorio, L., McQueen, J. F., Bloom, C. A., Zimmermann Rollin, I., Venkitasubramony, V., Santiago, L. E., Chang, M., & Breslin, J. W. (2026). Heavy alcohol consumption attenuates human mesenteric artery responsiveness to sigma receptor-1 ligands. American journal of physiology. Heart and circulatory physiology, 330(1), H200–H211. https://doi.org/10.1152/ajpheart.00453.2025

Disciplines

Medicine and Health Sciences

PubMedID

41324990

Department(s)

Fellows and Residents

Document Type

Article