KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone-independent manner.
Publication/Presentation Date
6-1-2026
Abstract
Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity. Polycystic ovary syndrome (PCOS) is characterized by accelerated gonadotropin hormone production leading to reproductive and metabolic deficits, including oligomenorrhea, infertility, and an increased risk of type 2 diabetes mellitus. Hypothalamic kisspeptin is a key regulator of gonadotropin secretion, and disruptions in kisspeptin signaling result in abnormal gonadotropin pulsatility. Emerging evidence also implicates kisspeptin in energy metabolism. This study investigates the neuroendocrine mechanisms by which kisspeptin within KNDy neurons influences metabolic homeostasis. Using a Pdyn-Cre/Kiss1
Volume
38
Issue
6
First Page
70208
Last Page
70208
ISSN
1365-2826
Published In/Presented At
Nandankar, N., Negrón, A. L., Ganesh, H., Youssef, N., Farooq, S., Al-Samerria, S., Levine, J. E., & Radovick, S. (2026). KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone-independent manner. Journal of neuroendocrinology, 38(6), e70208. https://doi.org/10.1111/jne.70208
Disciplines
Medicine and Health Sciences
PubMedID
42219677
Department(s)
Fellows and Residents
Document Type
Article