Consensus Review on Strategies to Improve Delivery Across the BBB Including Focused Ultrasound.
Publication/Presentation Date
5-21-2024
Abstract
Drug delivery to the central nervous system (CNS) has been a major challenge for CNS tumors due to the impermeability of the blood brain barrier (BBB). There have been a multitude of techniques aimed at overcoming the BBB obstacle aimed at utilizing natural transport mechanisms or bypassing the BBB which we review here. Another approach that has generated recent interest in the recently published literature is to use new technologies (Laser Interstitial Thermal Therapy, LITT; or Low Intensity Focused Ultrasound, LIFU) to temporarily increase BBB permeability. This review overviews the advantages, disadvantages, and major advances of each method. LIFU has been a major area of research to allow for chemotherapeutics to cross the BBB which has a particular emphasis in this review. While most of the advances remain in animal studies, there are an increasing number of translational clinical trials which will have results in the next few years.
ISSN
1523-5866
Published In/Presented At
Piper, K., Kumar, J. I., Domino, J., Tuchek, C., & Vogelbaum, M. A. (2024). Consensus Review on Strategies to Improve Delivery Across the BBB Including Focused Ultrasound. Neuro-oncology, noae087. Advance online publication. https://doi.org/10.1093/neuonc/noae087
Disciplines
Medicine and Health Sciences
PubMedID
38770775
Department(s)
Fellows and Residents
Document Type
Article