Correlation of Leptin in Patients With Type 2 Diabetes Mellitus.
Publication/Presentation Date
4-1-2024
Abstract
The exponential increase in diabetes mellitus (DM) poses serious public health concerns. In this review, we focus on the role of leptin in type 2 DM. The peripheral actions of leptin consist of upregulating proinflammatory cytokines which play an important role in the pathogenesis of type 2 DM and insulin resistance. Moreover, leptin is known to inhibit insulin secretion and plays a significant role in insulin resistance in obesity and type 2 DM. A literature search was conducted on Medline, Cochrane, Embase, and Google Scholar for relevant articles published until December 2023. The following search strings and Medical Subject Headings (MeSH terms) were used: "Diabetes Mellitus," "Leptin," "NPY," and "Biomarker." This article aims to discuss the physiology of leptin in type 2 DM, its glucoregulatory actions, its relationship with appetite, the impact that various lifestyle modifications can have on leptin levels, and, finally, explore leptin as a potential target for various treatment strategies.
Volume
16
Issue
4
First Page
57667
Last Page
57667
ISSN
2168-8184
Published In/Presented At
Manglani, K., Anika, N. N., Patel, D., Jhaveri, S., Avanthika, C., Sudan, S., Alimohamed, Z., & Tiwari, K. (2024). Correlation of Leptin in Patients With Type 2 Diabetes Mellitus. Cureus, 16(4), e57667. https://doi.org/10.7759/cureus.57667
PubMedID
38707092
Department(s)
Fellows and Residents
Document Type
Article