Norepinephrine-mediated regulation of endogenous Aβ

Authors

• Isaiah Hoffman
• Jennifer A Ross
• Marissa Tumasz
• Steven A Thomas
• Elisabeth J Van Bockstaele

Publication/Presentation Date

7-24-2026

Abstract

The locus coeruleus (LC), a cluster of noradrenergic neurons in the dorsal pons, is the brain's main source of norepinephrine (NE), crucial for memory, cognition, and stress response. NE dysregulation has been linked to mood disorders, chronic stress, and neurodegenerative diseases such as Alzheimer's disease (AD). Amyloid-β

ISSN

3091-4981

Published In/Presented At

Hoffman, I., Ross, J. A., Tumasz, M., Thomas, S. A., & Van Bockstaele, E. J. (2026). Norepinephrine-mediated regulation of endogenous Aβ42 peptide levels: effects of noradrenergic depletion and restoration. MedScience, 10.1007/s11684-026-1242-y. Advance online publication. https://doi.org/10.1007/s11684-026-1242-y

Disciplines

Medicine and Health Sciences

PubMedID

42493706

Department(s)

Fellows and Residents

Document Type

Article