Independent regulation of M-CSF and G-CSF gene expression in human monocytes.
Publication/Presentation Date
6-1-1988
Abstract
The macrophage and granulocyte colony-stimulating factors, M-CSF and G-CSF, act in vitro to induce proliferation and differentiation of monocyte and granulocyte progenitor cells, respectively. We show here that both of these CSFs can be produced by stimulated human blood monocytes, but the M-CSF and G-CSF genes are independently regulated. Recombinant human interleukin-3 (IL-3) and GM-CSF primarily induce expression of the M-CSF gene and secretion of M-CSF, whereas bacterial lipopolysaccharide primarily induces expression of the G-CSF gene and secretion of G-CSF. These results suggest that under different conditions of in vitro stimulation the monocyte secretes factors that could lead selectively to either granulocyte or monocyte production.
Volume
71
Issue
6
First Page
1529
Last Page
1532
ISSN
0006-4971
Published In/Presented At
Vellenga, E., Rambaldi, A., Ernst, T. J., Ostapovicz, D., & Griffin, J. D. (1988). Independent regulation of M-CSF and G-CSF gene expression in human monocytes. Blood, 71(6), 1529–1532.
Disciplines
Medicine and Health Sciences
PubMedID
2453227
Department(s)
Fellows and Residents
Document Type
Article