Secretion of interleukin-1 by acute myeloblastic leukemia cells in vitro induces endothelial cells to secrete colony stimulating factors.
Publication/Presentation Date
10-1-1987
Abstract
The interaction of acute myeloblastic leukemia (AML) cells with stromal cells was investigated by adding AML-conditioned media to cultures of human endothelial cells. This conditioned media contained factors that induced expression of both the granulocyte macrophage colony-stimulating factor (GM-CSF) and granulocyte CSF (G-CSF) genes and release of colony stimulating activity from endothelial cells. The conditioned media contained interleukin-1 (IL-1) bioactivity and the endothelial cell stimulatory activity was partially neutralized by anti-IL-1 antiserum. Constitutive expression of the IL-1-beta gene was detected in ten of 17 AML cases analyzed. These results suggest that the unregulated secretion of IL-1 by AML cells can induce stromal cells in vitro to overproduce CSFs. This could contribute to the unrestricted growth of AML cells.
Volume
70
Issue
4
First Page
1218
Last Page
1221
ISSN
0006-4971
Published In/Presented At
Griffin, J. D., Rambaldi, A., Vellenga, E., Young, D. C., Ostapovicz, D., & Cannistra, S. A. (1987). Secretion of interleukin-1 by acute myeloblastic leukemia cells in vitro induces endothelial cells to secrete colony stimulating factors. Blood, 70(4), 1218–1221.
Disciplines
Medicine and Health Sciences
PubMedID
3498521
Department(s)
Fellows and Residents
Document Type
Article