Relationships between block-of-twitch and train-of-four fade in the mouse phrenic nerve-diaphragm preparation.
Publication/Presentation Date
4-1-1991
Abstract
The relationships between the block-of-twitch and train-of-four fade in the presence of nondepolarizing neuromuscular blocking drugs (d-tubocurarine, vecuronium and pancuronium) were examined in vitro by measuring the contractile tension from mouse phrenic nerve-diaphragm preparations. The slope of the block/fade relationship differed between onset of and recovery from neuromuscular block following single doses of d-tubocurarine, vecuronium or pancuronium. Decreasing the dose of d-tubocurarine or using a divided dose technique to accelerate onset (i.e., priming) increased the amount of fade for a given amount of block. In addition, the block/fade relationships for cumulative dosing and sequential dilution were the same when measurements were made at steady-state for several doses. It is concluded that the block/fade relationship in the mouse phrenic nerve-diaphragm preparation is variable, and is related to the time course of the neuromuscular block. In addition, the block/fade relationships for d-tubocurarine, vecuronium and pancuronium did not differ when determined at steady-state.
Volume
38
Issue
3
First Page
401
Last Page
407
ISSN
0832-610X
Published In/Presented At
Storella, R. J., Slomowitz, S. A., & Rosenberg, H. (1991). Relationships between block-of-twitch and train-of-four fade in the mouse phrenic nerve-diaphragm preparation. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 38(3), 401–407. https://doi.org/10.1007/BF03007631
Disciplines
Medicine and Health Sciences
PubMedID
1674678
Department(s)
Fellows and Residents
Document Type
Article