On the safety of 5-[125I]iodo-2'-deoxyuridine--Preclinical evaluation in swine.
Publication/Presentation Date
1-1-1996
Abstract
To increase tumor incorporation and minimize hepatic degradation of radio-IUdR, compartmental administration routes are being considered as an alternative to intravenous (i.v.) injections. Although there are significant data on the biodistribution and some reports on radiotoxicity of i.v.-administered 125IUdR, similar results for other routes of delivery are not available. We have undertaken a series of experiments intended to examine radiation effects of 125IUdR after intravesical (3 swine; eight 3 mCi doses at 4-day intervals), intracarotid (3 swine; two 10 mCi doses at 2-week intervals), and intra-aortic (5 swine, single dose of 10 mCi) administration in a swine model. Liver, renal functions, and complete blood counts were monitored throughout the duration of the experiment. Pharmacokinetics, systemic distribution of radioactivity and metabolites were measured. The normal tissue 125IUdR uptake and histology were determined after necropsy. No adverse systemic effects were identified. Clinical observations, laboratory data, and necropsy results were within normal range.
Volume
35
Issue
7
First Page
925
Last Page
933
ISSN
0284-186X
Published In/Presented At
Baranowska-Kortylewicz, J., Dalrymple, G. V., Harrison, K. A., Holdeman, K. P., Sharp, J. G., Cohen, S. M., Lieberman, R. P., Schneiderman, M. H., Clausen, S. R., Hoffman, D., Lai, J., Schneiderman, G. S., & Helseth, L. (1996). On the safety of 5-[125I]iodo-2'-deoxyuridine--Preclinical evaluation in swine. Acta oncologica (Stockholm, Sweden), 35(7), 925–933. https://doi.org/10.3109/02841869609104047
Disciplines
Medicine and Health Sciences
PubMedID
9004773
Department(s)
Fellows and Residents
Document Type
Article